A team led by Ernesto Di Mauro at Sapienza University of Rome may point a way to solving the problem of the origin of life on Earth. It is thought most likely that life developed from RNA replicators. The problem here has been as to how the first replicator emerged, with an impossibly high probability against the molecules of the first replicator arranging themselves in a chain of the right order simply by chance. The nucleotides that make up RNA do not tend to form chains without a catalyst, but the catalysts that act to produce such chains are proteins, which are themselves made by RNA. This creates a classic chicken and egg conundrum, but long before there were either chickens or eggs on Earth.